Author

Hugo Calderón

Hospital Clínic de BarcelonaORCID 0000-0002-8902-4302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alba Rodríguez-GarcíaiD· 1 shared Aleix PratiD· 1 shared Álvaro Urbano-IspizúaiD· 1 shared Berta MarzaliD· 1 shared Europa Azucena González‐NavarroiD· 1 shared Guillem Colell· 1 shared Guim Cascalló· 1 shared Irene Andreu-SaumelliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alba Rodríguez-GarcíaORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Context-dependent tonic signaling shapes the performance and manufacturability of a 4-1BB- based HER2 CAR-T cell therapy

Laura Angelats, Berta Marzal, Alba Rodríguez-García, Marta Español‐Rego, Teresa Lobo‐Jarne, María Hernández‐Sánchez, Guim Cascalló, Salut Colell, Marta Giménez-Alejandre, Guillem Colell, Joan Castellsagué, Irene Andreu-Saumell, Hugo Calderón, Patricia Galván, Álvaro Urbano-Ispizúa, , Sònia Guedan

This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.

bioRxiv · May 14, 2026 · PreprintImmunology