Author

Sven Kratochvil

BioNTech (Germany)ORCID 0000-0002-0446-2371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra MalziD· 2 shared Candice Morin· 2 shared Christiane StadleriD· 2 shared Felix TolksdorfiD· 2 shared Imke Gerhard· 2 shared Jan P. BogeniD· 2 shared Johannes NelkeiD· 2 shared Leyla Fischer· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexandra MalzORCID

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Author profile →

3 papers

Recent·Most cited

Durable suppression of viremia by lipid nanoparticle-formulated RNA encoding for a highly potent HIV-1 neutralizing antibody

Sophie Sayettat, Felix Tolksdorf, Robin Johannson, Johannes Nelke, Alexandra Malz, Leyla Fischer, Imke Gerhard, Nathalie Ullrich, Ursula Ellinghaus, Christiane Stadler, Jan P. Bogen, Candice Morin, Jacqueline Knüfer, Ricarda Stumpf, Philipp Schommers, , Henning Gruell

This study demonstrates that lipid nanoparticle-formulated RNA encoding a potent HIV-1 neutralizing antibody can durably suppress viremia in humanized mice.

bioRxiv · Sep 19, 2026 · PreprintImmunology

RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics

Felix Tolksdorf, Johannes Nelke, Robin Johannson, Janina Caesar, Anuhar Chaturvedi, Anja Kopp, Leyla Fischer, Alexandra Malz, Sven Kratochvil, Imke Gerhard, Jan P. Bogen, Candice Morin, Maximilian Kullmann, Michael S. Seaman, Georgia D. Tomaras, , Valentin Le Douce

This paper presents an RNA-encoded bNAb platform for in vivo production of PGT121-LS, showing prolonged half-life and potent neutralization in mice and non-human primates.

Molecular Therapy — Nucleic Acids · Sep 17, 2026Peer-reviewedImmunology

A Single Structure-Derived Computational Metric Predicts High-Affinity Antibody Selection Against a Malaria Antigen

Gordon A. Dale, Bingxian Chen, Ja‐Hyun Koo, Martina Wecera, Sven Kratochvil, Facundo D. Batista

The paper develops a computational metric from protein structures to predict high-affinity malaria antibodies, demonstrating its effectiveness with two PfCSP-targeting antibodies.

bioRxiv · Sep 30, 2025 · PreprintImmunology