RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics
Felix Tolksdorf, Johannes Nelke, Robin Johannson, Janina Caesar, Anuhar Chaturvedi, Anja Kopp, Leyla Fischer, Alexandra Malz, Sven Kratochvil, Imke Gerhard, Jan P. Bogen, Candice Morin, Maximilian Kullmann, Michael S. Seaman, Georgia D. Tomaras, , Valentin Le Douce
This paper presents an RNA-encoded bNAb platform for in vivo production of PGT121-LS, showing prolonged half-life and potent neutralization in mice and non-human primates.
Molecular Therapy — Nucleic Acids · Sep 17, 2026Peer-reviewedImmunology