Author

Henning Gruell

University of CologneORCID 0000-0002-0725-7138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Florian KleiniD· 4 shared Ricarda Stumpf· 4 shared Christoph KreeriD· 3 shared Jacqueline Knüfer· 3 shared Lutz GieselmanniD· 3 shared Malena Rohde· 3 shared Michael S. SeamaniD· 3 shared Philipp SchommersiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Florian KleinORCID

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4 papers

Recent·Most cited

Durable suppression of viremia by lipid nanoparticle-formulated RNA encoding for a highly potent HIV-1 neutralizing antibody

Sophie Sayettat, Felix Tolksdorf, Robin Johannson, Johannes Nelke, Alexandra Malz, Leyla Fischer, Imke Gerhard, Nathalie Ullrich, Ursula Ellinghaus, Christiane Stadler, Jan P. Bogen, Candice Morin, Jacqueline Knüfer, Ricarda Stumpf, Philipp Schommers, , Henning Gruell

This study demonstrates that lipid nanoparticle-formulated RNA encoding a potent HIV-1 neutralizing antibody can durably suppress viremia in humanized mice.

bioRxiv · Sep 19, 2026 · PreprintImmunology

Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals

Katharina Daniel, Leon Ullrich, Denis Ruchnewitz, Matthijs Meijers, Nico Joël Halwe, Ursula Wild, Jan Eberhardt, Jacob Schön, Ricarda Stumpf, Maike Schlotz, Marie Wunsch, Luana Girao Lessa, Elsayed M. Abdelwhab, Maryna Kuryshko, Christopher Dietrich, , Florian Klein

The paper assesses pre-existing humoral immunity against H5N1 clade 2.3.4.4b in unexposed individuals and finds low but distinct cross-neutralizing titers.

Immunity · Jan 30, 2026Peer-reviewedImmunology

Identification of a broad and potent V3 glycan site bNAb targeting anN332gp120 glycan-independent epitope

Lutz Gieselmann, Andrew T. DeLaitsch, Malena Rohde, Caelan E. Radford, Johanna Worczinski, Anna Momot, Elvin Ahmadov, Judith A. Burger, Colin Havenar‐Daughton, Sharvari Deshpande, Federico Giovannoni, Davide Corti, Christoph Kreer, Meryem Seda Ercanoglu, Philipp Schommers, , Florian Klein

This paper identifies a potent, broad neutralizing antibody targeting a glycan-independent V3 epitope on HIV-1 Env, showing enhanced neutralization potency and resistance to escape mutations.

bioRxiv · Sep 5, 2025 · PreprintImmunology

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

Lutz Gieselmann, Andrew T. DeLaitsch, Malena Rohde, Henning Gruell, Christoph Kreer, Meryem Seda Ercanoglu, Harry B. Gristick, Philipp Schommers, Elvin Ahmadov, Caelan E. Radford, Andrea Mazzolini, Lily Zhang, Anthony P. West, Johanna Worczinski, Anna Momot, , Florian Klein

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.

bioRxiv · Aug 27, 2025 · PreprintImmunology