Douglas C. Wu

The paper identifies thousands of FLEXIs in human cells, links them to RNA-binding proteins, and suggests their potential as biomarkers.

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

The paper improves TGIRT-seq methods by reducing adapter dimer formation and correcting 5- and 3-end biases, enhancing transcriptome coverage and library construction efficiency.

This study compares alignment-free and alignment-based RNA-seq pipelines for total RNA quantification, finding alignment-free tools less accurate for small and lowly-expressed RNAs.