Author

Hubert Wyszkowski

University of GdańskORCID 0000-0002-0450-6557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

Agnieszka A. KlosowskaiD· 2 shared Bartłomiej TomiczekiD· 2 shared Dominik PurzyckiiD· 2 shared Katarzyna KalinowskaiD· 2 shared Agata Konieczna· 1 shared Aneta SzymańskaiD· 1 shared Brenda A. SchilkeiD· 1 shared Elizabeth Anne CraigiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Agnieszka A. KlosowskaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multi-Step Hsp70 Recruitment by Class B J-Domain Proteins Drives Efficient Protein Disaggregation

Hubert Wyszkowski, Agata Konieczna, Maria Pokornowska, Wiktoria Sztangierska, Filip Kuś, Maciej Malolepszy, Katarzyna Kalinowska, Dominik Purzycki, Bartłomiej Tomiczek, Krzysztof Liberek, Agnieszka A. Klosowska

This study examines how Class B J-Domain Proteins enhance Hsp70-mediated protein disaggregation through autoinhibition and EEVD motif interactions.

bioRxiv · Feb 9, 2026 · PreprintBiochemistry

Origin of Class B J-domain proteins involved in amyloid transactions

Przemyslaw Domanski, Milena Stolarska, Katarzyna Kalinowska, Dominik Purzycki, Brenda A. Schilke, Hubert Wyszkowski, Marcin Pitek, Aneta Szymańska, Katarzyna Bury, Jacek Czub, Agnieszka A. Klosowska, Elizabeth Anne Craig, Jarosław Marszałek, Bartłomiej Tomiczek

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedEvolutionary Biology