Jean‐Bernard Denault

This study shows that SNX2, but not SNX1, regulates MET endosomal trafficking and signaling in HCT116 cells, leading to enhanced AKT activation and poorer CRC patient survival.

The paper identifies altPIDD1 as the primary protein product of the PIDD1 gene, showing higher expression and cytoskeletal interactions compared to the known PIDD1 protein.

This study shows that SNX1 and SNX2 regulate MET trafficking, affecting phosphorylation of MET and AKT but not ERK1/2, and influence apoptosis resistance in CRC cells.