Author

Stephanie S. Holden

Gladstone InstitutesORCID 0000-0002-0513-5444Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jeanne T. PaziD· 2 shared Alejandro Osorio-ForeroiD· 1 shared Allison R. MorningstariD· 1 shared Andrea J. TenneriD· 1 shared Andrew D. NelsoniD· 1 shared Andrew H. ChangiD· 1 shared Anita LüthiiD· 1 shared Atehsa SahaguniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Jeanne T. PazORCID

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2 papers

Recent·Most cited

NeuroscienceNaturePeer-reviewedSep 17, 2025

CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

Serena Tamura, Andrew D. Nelson, Perry W.E. Spratt…·Kevin J. Bender

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

47 citationstop 1%

mouseexperimental assay

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NeuroscienceSciencePeer-reviewedSep 9, 2021

Complement factor C1q mediates chronic neuron loss and inflammation post-brain injury

Stephanie S. Holden, Fiorella Carla Grandi, Oumaima Aboubakr…·Jeanne T. Paz

This study shows that C1q mediates chronic neuron loss and inflammation after brain injury by targeting the corticothalamic circuit in mice.

133 citationstop 1%

mouseexperimental assay

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