Anita Lüthi

This study identifies KCNH1 as a cell cycle-regulated potassium channel that modulates plasma membrane potential, thereby influencing the efficiency of cell-penetrating peptide (CPP) direct translocation.

The paper identifies a conserved locus coeruleus (LC) fMRI signature across sleep, anesthesia, and wakefulness, showing its impact on brain-state transitions and functional connectivity.

The paper shows that vagal afferent activation induces brain-body cooling and NREM-sleep-like states while increasing locus coeruleus activity.

This study uses pupil size measurements during sleep to explore arousal level dynamics and their relationship with sleep oscillations and auditory responses.

This study identifies GABAergic neurons in the hypothalamic preoptic area that regulate REM sleep homeostasis by responding to REM sleep restriction and mediating rebound.

This study shows that LC activity partitions NREM sleep into brain and autonomic states that regulate the NREM-REM cycle, with high activity enabling microarousals and low activity required for REMS entries.

The paper shows that frontal cortex uses a specialized pathway to control the thalamic reticular nucleus through L5 pyramidal cells, distinct from other cortical regions.

This study shows that autophagy in parvalbumin interneurons is essential for synaptic proteostasis, inhibitory transmission, and memory, but not for Purkinje cells.

The paper shows that noradrenaline fluctuations during non-REM sleep influence sleep spindle clustering and heart rate variations through thalamic circuits.

This study shows that C1q mediates chronic neuron loss and inflammation after brain injury by targeting the corticothalamic circuit in mice.

This study identifies a thalamic reticular circuit that integrates sensory cues with internal head-direction signals to regulate spatial navigation strategies.