Spleen tyrosine kinase inhibition mitigates hemin-induced thromboinflammation in the lung and kidney of sickle cell mice
Juma El-Awaisi, Gina Perrella, Nicolas Mayor, V. V. Tinkova, Simon J. Cleary, Beata Grygielska, Steve P. Watson, Jordan D. Dimitrov, Alexander G. Brill, Eman Hassan, Phillip L.R. Nicolson, Dean Philip John Kavanagh, Neena Kalia, Julie Rayes
This study shows that Syk inhibition reduces hemin-induced thromboinflammation and improves perfusion in the lungs and kidneys of sickle cell mice.
Arteriosclerosis Thrombosis and Vascular Biology · Aug 15, 2025Peer-reviewedPathology