Filipa M. Pereira

The paper reports chemoselective halogenation of Premarineosin A, yielding analogs with retained antiplasmodial activity against both sensitive and resistant Plasmodium falciparum strains.

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

The paper designs an engineered biosynthetic pathway in E. coli to produce (+)-brevianamides A and B, achieving a 46% yield with a 92:8 diastereomeric ratio.

The paper shows that parts of the TCA cycle operate in the nucleus, challenging the canonical view of metabolic compartmentalization.

The paper identifies co-translational assembly domains in proteins that facilitate interactions between nascent chains and fully synthesized subunits, revealing their role in regulating complex assembly pathways.

This paper predicts the evolution of fitness-costly traits by designing selection niches using metabolic models and validates it in yeast for increased aroma compound secretion.