Author

Dario Melgari

IRCCS Policlinico San DonatoORCID 0000-0002-0563-8041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Ilaria RivoltaiD· 2 shared Rachele PrevostiniiD· 2 shared Serena CalamaioiD· 2 shared Aiswarya Dev· 1 shared Alexander D. CorbettiD· 1 shared Alice NevoneiD· 1 shared Andreas KoschinskiiD· 1 shared Annika WinboiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPhysiology

Ilaria RivoltaORCID

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2 papers

Recent·Most cited

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

Emily Akerman, Rebecca A.B. Burton, Eva A. Rog‐Zielinska, Annika Winbo, Daniel Aston, Florian Falter, R. B. A. Mu-u-min, Matthew J. Read, Samuel J. Bose, Pawel Swietach, Jingyu Wang, Alexander D. Corbett, Andreas Koschinski, Serena Calamaio, Dario Melgari, , Derek A. Terrar

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

Cardiovascular Research · Sep 19, 2026Peer-reviewedPhysiology

Exploring light chain cardiotoxicity in AL amyloidosis: Impact on hiPSC-derived Cardiomyocyte Activity

Serena Calamaio, Anthony Frosio, Dario Melgari, Luca Broggini, Federica Sonzini, Rachele Prevostini, Davide Pignatelli, Luigi Anastasia, Carlo Pappone, Alice Nevone, Giovanni O. Palladini, Mario Nuvolone, Stéfano Ricagno, Ilaria Rivolta

This study uses hiPSC-derived cardiomyocytes to show that cardiotoxic light chains reduce electrophysiological function, while non-toxic light chains have no effect.

Amyloid · Jun 19, 2026Peer-reviewedPathology