Su-Youne Chang

This paper develops a porcine model of mesial temporal lobe epilepsy using kainic acid and an implantable device to study seizures and electrophysiological features.

The paper assesses a novel mitochondrial complex I inhibitor, C458, in vitro and in vivo, showing it protects against Aβ toxicity, improves brain energetics, and reduces inflammation in Alzheimer's disease models.

This study evaluates eOPN3, a red-shifted inhibitory opsin, in a pig model of Temporal Lobe Epilepsy to modulate seizure activity using optogenetics.

This study demonstrates the feasibility of endovascular vagus nerve stimulation using electrodes in the internal jugular vein, showing that electrode positioning is critical for effective VN activation.

This study shows that specific MHC class I molecules on brain endothelium regulate CD8 T cell activity and neuropathology in experimental cerebral malaria.

The paper shows that partial inhibition of mitochondrial complex I protects against neurodegeneration in Alzheimer's mice by improving energy homeostasis, synaptic function, and reducing inflammation.

This study shows that inhibiting mitochondrial complex I with CP2 reduces pTau levels and improves cognitive and metabolic function in 3xTg-AD mice.