Author

Joshua A. Hinckley

Broad InstituteORCID 0000-0002-0575-5045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

John Christopher LoveiD· 2 shared Adel Atari· 1 shared Amanda M. Del RosarioiD· 1 shared Brendan Dang· 1 shared Charles A. WhittakeriD· 1 shared Harini NarayananiD· 1 shared John J. Clark· 1 shared Kerry Routenberg LoveiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

John Christopher LoveORCID

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2 papers

Recent·Most cited

Accelerating Cell Culture Media Development Using Bayesian Optimization-Based Iterative Experimental Design

Harini Narayanan, Joshua A. Hinckley, Rachel M. Barry, Brendan Dang, Lenna A. Wolffe, Adel Atari, Yuen‐Yi Tseng, John Christopher Love

This paper uses Bayesian optimization to accelerate cell culture media development, achieving better results with fewer experiments in two applications.

Nature Communications · Jul 1, 2025Peer-reviewedBioengineering

CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome

Neil C. Dalvie, Timothy R. Lorgeree, Yuchen Yang, Sergio A. Rodriguez‐Aponte, Charles A. Whittaker, Joshua A. Hinckley, John J. Clark, Amanda M. Del Rosario, Kerry Routenberg Love, John Christopher Love

The paper uses CRISPR-Cas9 to knock out endogenous secreted proteins in Komagataella phaffii, increasing recombinant protein production by 20x.

Microbial Cell Factories · Jul 31, 2024Peer-reviewedBioengineering