Glk1p is an actin fold metabolic enzyme whose polymerization is sensitive to nucleotide state
Michael D. Carver, Phillip Kyriakakis, Rachel M. Barry, Elena Meseguer Monfort, Andrés E. Leschziner, Mark A. Herzik, James E. Wilhelm
This study identifies glucose 6-phosphate (G6P) as a second trigger for Glk1p polymerization and shows that ADP causes filament disassembly, linking metabolic state to enzyme polymerization.
bioRxiv · Jul 10, 2026 · PreprintCell Biology