The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Nature Genetics · Oct 21, 2024Peer-reviewedGenetic & Genomic Medicine

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia Liliana Satizábal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano A, Aniket Mishra, , Marcio Almeida

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

bioRxiv · Jun 19, 2019 · PreprintGenetics

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Claudia Liliana Satizábal, Hieab H.H. Adams, Derrek P. Hibar, Charles C. White, Jason L. Stein, Markus R. Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Albert V. Smith, Joshua C. Bis, Xueqiu Jian, Michelle Luciano A, Edith Hofer, Alexander Teumer, Sven J. van der Lee, , Lachlan T. Strike

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

bioRxiv · Aug 28, 2017 · PreprintGenetics