Cell-specific RNA isoform remodeling in the aging mouse brain
Abid Rehman, Megan F. Duffy, Katarína Grešová, Cédric Belair, Na Yang, Lin Wang, Christopher Tai-Yi Lee, Matthew John Payea, Sulochan Malla, Showkat Ahmad Dar, Payel Sen, Mark Cookson, Manolis Maragkakis
This study identifies cell-type-specific RNA isoform changes in aging mouse brain using single-cell and long-read sequencing, revealing altered coding potential and senescence markers in immune cells.
bioRxiv · Jun 5, 2025 · PreprintGenomics