Payel Sen

Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

This study shows cyclin D1 regulates hepatic gene networks and metabolic responses to feeding, with non-cell cycle roles in aging, MASLD, and C. elegans overnutrition.

This study identifies cell-type-specific RNA isoform changes in aging mouse brain using single-cell and long-read sequencing, revealing altered coding potential and senescence markers in immune cells.

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.