Giovanni Spagnolli

This paper identifies a folding intermediate of Cyclin D1 as a target for selective degradation, showing that pharmacological interference with this state inhibits tumor growth and overcomes resistance to CDK4/6 inhibitors.

The paper identifies cryptic phosphosites in the human proteome that are buried in the protein core and may influence folding and degradation, with implications for cancer.

This study shows that defective cyclophilin A (PPIA) leads to TDP-43 proteinopathy, contributing to ALS and FTD by disrupting TDP-43 function and causing neurodegeneration.

The paper studies zebrafish impg2a and impg2b proteoglycans, their expression patterns, and structural conservation to model IMPG2-related retinal diseases.