Moshe Biton

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

This study shows intestinal stem cells use TLR2 to sense microbes, coordinating epithelial defense and regeneration.

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

The paper develops an optogenetics-integrated gut organ culture system to study enteric neuron dynamics and their impact on gut homeostasis, revealing distinct neuronal roles in immune and barrier functions.

The paper shows that persistent ECM scarring in the colon reprograms intestinal stem cells to drive chronic inflammation through a modECM niche.

This study uses single-cell RNA sequencing to identify subtypes and proliferation patterns in small intestine neuroendocrine tumors, revealing non-proliferative neuroendocrine cells and proliferative non-malignant cells.

This study uses longitudinal scRNA-seq data from a mouse colitis model to build ODE-based models of immune dynamics, validating predictions with flow cytometry and human IBD gene expression data.

The paper introduces a method to prioritize causal genes for complex traits by integrating GWAS data with gene expression and biological data, achieving high precision in gene-trait pair identification.

The paper was withdrawn due to the inclusion of confidential information about a third party.

This study shows that T helper cells interact with intestinal stem cells via MHCII to regulate their renewal and differentiation, with distinct effects based on Th subtype and cytokine signaling.