Author

Sacha Lebon

Weizmann Institute of ScienceORCID 0000-0002-4650-2132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 5 Organism:mouse· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Aviya Habshush MenachemiD· 5 shared Moshe BitoniD· 5 shared V. V. Holiar· 5 shared Barak Toval· 4 shared Avital Sarusi-PortugueziD· 3 shared Carmel SocheniD· 3 shared Natalia DavidzohniD· 3 shared Idan AdiriD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersImmunology

Aviya Habshush MenachemORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity

Carmel Sochen, Sacha Lebon, Aviya Habshush Menachem, Avital Sarusi-Portuguez, V. V. Holiar, Vladislav Rudenko, Barak Toval, Jingjing Liu, Yishai Levin, Ella Vaaknin, Noa Rosenthal, Noa Tiferet, Irit Orr, Shifra Ben‐Dor, Rebecca Haffner‐Krausz, , Moshe Biton

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

bioRxiv · Jul 26, 2026 · PreprintImmunology

Elucidating early intestinal stem cell response to bacterial infection

Sacha Lebon, Aviya Habshush Menachem, Natalia Davidzohn, A. Katz, Noa Wigoda, T Braun, D. Yahalomi, Ron Rotkopf, V. V. Holiar, T. Dadosh, Smadar Levin‐Zaidman, Nili Dezorella, I. Goliand, Meital Kupervaser, Shira Leebhoff, , Moshe Biton

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

Nature Immunology · May 12, 2026Peer-reviewedImmunology

TLR2-mediated microbial sensing by intestinal stem cells coordinates epithelial antimicrobial defense.

Aviya Habshush Menachem, Sacha Lebon, Christoph Killian, V. V. Holiar, Avital Sarusi-Portuguez, Natalia Davidzohn, Barak Toval, Carmel Sochen, Smadar Levin‐Zaidman, Nili Dezorella, Leilah Otikovs, Deborah Duran, Ilan Kent, Myriam Grunewald, Lorenz Adlung, Moshe Biton

This study shows intestinal stem cells use TLR2 to sense microbes, coordinating epithelial defense and regeneration.

bioRxiv · May 7, 2026 · PreprintImmunology

Epithelial MHC II antigen presentation dynamically informs intestinal homeostasis and injury

V. V. Holiar, Vladislav Rudenko, Chen Weller, Mariia Naumova, Sacha Lebon, Marco Canella, Petro Busko, Avital Sarusi-Portuguez, Tali Shalit, Aviya Habshush Menachem, Idan Adir, Zachary Petrover, Polina Greenberg, Corine Katina, Polina Gradchenko, , Moshe Biton

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

bioRxiv · Mar 20, 2026 · PreprintImmunology

Persistent ECM Scarring Reprograms Intestinal Stem Cells to Drive Chronic Inflammation

Idan Adir, Carmel Sochen, Aviya Habshush Menachem, Sacha Lebon, Barak Toval, V. V. Holiar, Natalia Davidzohn, Tomer‐Meir Salame, Irit Rosenhek‐Goldian, Simonas Savickas, Fabio Sabino, Inna Solomonov, Ulrich auf dem Keller, Moshe Biton, Irit Sagi

The paper shows that persistent ECM scarring in the colon reprograms intestinal stem cells to drive chronic inflammation through a modECM niche.

bioRxiv · Jun 8, 2025 · PreprintImmunology