Yan Juan Xu

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

This study investigates the role of Notum and Wnt5a in regulating the timing of cartilaginous mesenchymal condensations in developing trachea, showing their impact on chondrogenesis and tracheal lumen formation.

This study identifies STAT1 as a driver of LAM cell survival and tumor growth by promoting PD-L1 expression and immune evasion in TSC2-deficient models.

This study shows PRDM3 and PRDM16 regulate chromatin accessibility to support NKX2-1-driven alveolar epithelial differentiation and function, with loss leading to respiratory failure and lineage infidelity.

The paper uses single-cell RNA sequencing to create a molecular map of newborn human lung cells and identifies cell type-specific developmental states and biomarkers.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

This study identifies Npt2b and pulmonary osteoclast-like cells as key regulators of phosphate homeostasis and microlith clearance in PAM.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

The paper introduces a web toolset called Lung-at-a-glance to integrate and visualize lung ontology, imaging, and single-cell omics data.