This study shows that stimulating the dorsolateral prefrontal cortex improves motor function in Parkinson's disease, particularly under cognitive load, by altering functional connectivity in the somato-cognitive action network.

bioRxiv · Sep 4, 2026 · PreprintNeuroscience

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium

Farid Rajabli, Penelope H. Benchek, Giuseppe Tosto, Nicholas A. Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan‐Ping Lee, Jacob Haut, Kara L. Hamilton‐Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, , Matthew P. Frosch

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.

medRxiv · Jul 6, 2023 · PreprintGenetic & Genomic Medicine

Manifestations of genetic risk for Alzheimer's Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+

Laura M. Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam Christian Naj, Nilüfer Ertekin‐Taner, Todd Eliot Golde, Leroy Hood, , Jeffrey Alan Kaye

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

Scientific Reports · Apr 12, 2022Peer-reviewedGenetics