NISC Comparative Sequencing Program

Description of two novel Corynebacterium species isolated from human nasal passages and skin

This paper describes two novel Corynebacterium species isolated from human nasal passages and skin, along with characteristics of two strains of a recently named species.

Skin microbiome composition and function in the development of atopic diseases during infancy

This study identifies distinct skin microbiome features associated with atopic phenotypes in infancy, including AD, FS, and FA, and their interactions with host genetics.

Investigation of the Fasciola Cinereum, Absent in BTBR mice, and Comparison with the Hippocampal Area CA2

The paper characterizes Avpr1b neuronal subpopulations in the fasciola cinereum and dorsal CA2 of mice, finding differences in gene expression between wildtype and BTBR mice, a model for autism.

A genome catalog of the early-life human skin microbiome

The paper presents a genome catalog of the early-life human skin microbiome, expanding diversity and improving classification rates using metagenomic data from infants and their mothers.

Genomic characterization of the C. tuberculostearicum species complex, a ubiquitous member of the human skin microbiome

This paper expands the genomic reference catalog of Corynebacterium species on human skin by sequencing isolates and analyzing metagenomic data, identifying two ribotypes and a potential new species.

Long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity

The paper uses long-read sequencing to identify pangenomic genes contributing to yeast phenotypic variation by resolving QTLs that are missed by short-read methods.

Clonal hematopoiesis in individuals with ANKRD26 or ETV6 germline mutations

This study examines clonal hematopoiesis risk in individuals with germline ANKRD26 or ETV6 mutations, finding that ANKRD26 carriers have elevated risk while ETV6 carriers do not.

A mouse model of occult intestinal colonization demonstrating antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae

This study develops a mouse model to study occult colonization and antibiotic-induced outgrowth of carbapenem-resistant Enterobacteriaceae, identifying factors that predict susceptibility to outgrowth.

A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation

The paper identifies gemin3 as a regeneration-essential gene in zebrafish and shows smn1, gemin3, and gemin5 inhibit the ErbB pathway to promote cell proliferation during tissue regeneration.

De Novo assembly of the goldfish (Carassius auratus) genome and the evolution of genes after whole genome duplication

This paper presents a high-quality goldfish genome assembly and analyzes gene evolution after whole genome duplication, identifying gene divergence patterns across tissues.

Cell-type specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

The paper identifies cell-type specific eQTLs in primary melanocytes, revealing novel melanoma susceptibility genes and associations with GWAS loci.

Functional Characterization of the Morpheus Gene Family

The paper characterizes the Morpheus gene family, identifying two subfamilies, expression patterns, and potential immune-related functions.