Jose F. Victorino

Temperature sensitive Mutant Proteome Profiling: a novel tool for the characterization of the global impact of missense mutations on the proteome

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

RNA Polymerase II CTD phosphatase Rtr1 prevents premature transcription termination

This paper shows that Rtr1 prevents premature transcription termination by restricting the NNS-dependent termination pathway and facilitating low-level elongation of noncoding transcripts.