Author

Aruna B. Wijeratne

Indiana University IndianapolisORCID 0000-0001-8366-2074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Amber L. MosleyiD· 3 shared Sarah A. Peck JusticeiD· 3 shared H. R. Sagara WijeratneiD· 2 shared Avery M. RunnebohmiD· 1 shared David A. BoothmaniD· 1 shared Edward A. MoteaiD· 1 shared Edward R. SimpsoniD· 1 shared Gitanjali RoyiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersSystems Biology

Amber L. MosleyORCID

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3 papers

Recent·Most cited

Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

Avery M. Runnebohm, H. R. Sagara Wijeratne, Sarah A. Peck Justice, Aruna B. Wijeratne, Gitanjali Roy, Jarrett J. Smith, Naveen Singh, Paul J. Hergenrother, David A. Boothman, Edward A. Motea, Amber L. Mosley

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

Journal of Proteome Research · Nov 6, 2026Peer-reviewedCancer Biology

Inflect: Optimizing Computational Workflows for Thermal Proteome Profiling Data Analysis

Neil A. McCracken, Sarah A. Peck Justice, Aruna B. Wijeratne, Amber L. Mosley

The paper optimizes the analysis workflow for Thermal Proteome Profiling data to improve the accuracy of protein stabilization/destabilization identification and provides an R-based tool for community use.

Journal of Proteome Research · Mar 4, 2021Peer-reviewedSystems Biology

Temperature sensitive Mutant Proteome Profiling: a novel tool for the characterization of the global impact of missense mutations on the proteome

Sarah A. Peck Justice, Monica P. Barron, Guihong D. Qi, H. R. Sagara Wijeratne, Jose F. Victorino, Edward R. Simpson, Jonah Z. Vilseck, Aruna B. Wijeratne, Amber L. Mosley

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

Journal of Biological Chemistry · Sep 2, 2020Peer-reviewedSystems Biology