Muhammad Tariq

Genome-wide binding of Multiple ankyrin repeats single KH domain reveals its role in maintenance of gene activation by trithorax group proteins in Drosophila

This study identifies Mask as a downstream effector of Trithorax group proteins in Drosophila, showing its role in maintaining gene activation by regulating H3K27ac and H3K27me3 levels.

Interplay between BALL and CBP maintains H3K27 acetylation on active genes in Drosophila

The paper shows BALL and CBP interact to maintain H3K27ac on active genes in Drosophila, revealing a new pathway for gene activation.

TISON: a next-generation multi-scale modeling theatre for in silico systems oncology

TISON is a web-based platform for multi-scale cancer modeling that integrates biomolecular data and patient-specific information to support drug target discovery and personalized therapeutics.

Polycomb requires Tcp-1η chaperonin for maintaining gene silencing in Drosophila

This study identifies Tcp-1η as a chaperonin subunit that interacts with Polycomb to maintain gene silencing in Drosophila, supporting its role in PcG targeting and chromatin association.

Kinome-wide RNAi screen uncovers role of Ballchen in maintenance of gene activation by trithorax group in Drosophila

The paper identifies Ballchen as a trithorax group regulator that counteracts Polycomb group repression by maintaining gene activation through histone modification.

In silico Drosophila Patient Model Reveals Optimal Combinatorial Therapies for Colorectal Cancer

This study develops an in silico Drosophila Patient Model to identify optimal combinatorial therapies for colorectal cancer using Boolean networks and patient-specific data.