Author

Philipp Gut

École PolytechniqueORCID 0000-0002-0689-9518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Gabriele CivilettoiD· 3 shared Alice Parisi· 2 shared Giulia Lizzo· 2 shared Aline Charpagne· 1 shared Anselm A. ZdebikiD· 1 shared Benjamin Weger· 1 shared Benoı̂t ViolletiD· 1 shared Bruce Spiegelman· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPharmacology & Toxicology

Gabriele CivilettoORCID

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3 papers

Recent·Most cited

Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties

Lisa Kiani, Gabriele Civiletto, Giulia Lizzo, Anselm A. Zdebik, Gini Brickell, Fahad Mahmood, Dionysios D Nalkos, Lucas Michaelides, Philip Eldridge, Emily Young, Hazel McPherson, Michelangelo Campanella, Philipp Gut, Claire Russell

This study identifies pregnenolone as a therapeutic candidate for CLN2 disease by suppressing seizures and normalizing lysosomal function in tpp1-/- zebrafish.

bioRxiv · Aug 26, 2025 · PreprintPharmacology & Toxicology

AMPK promotes induction of a tumor suppressor FLCN through activation of TFEB independently of mTOR

Caterina Collodet, Marc Foretz, Mária Deák, Laurent Bultot, Sylviane Métairon, Benoı̂t Viollet, Gregory C. Lefebvre, Frédéric Raymond, Alice Parisi, Gabriele Civiletto, Philipp Gut, Patrick Descombes, Kei Sakamoto

The paper identifies the AMPK-TFEB-FLCN axis as a regulator of cellular and metabolic homeostasis through gene expression and functional studies in mice and zebrafish.

The FASEB Journal · Aug 12, 2019Peer-reviewedMolecular Biology

PGC1a and Exercise Adaptations in Zebrafish

Alice Parisi, Peter Blattmann, Giulia Lizzo, Vivienne Stutz, Laura Strohm, Joy Richard, Gabriele Civiletto, Aline Charpagne, Frederic Raymond, Cedric Gobet, Benjamin Weger, Eugenia Migliavacca, Ruedi Aebersold, Bruce Spiegelman, Philipp Gut

This study shows that PGC1a induces mitochondrial biogenesis and exercise-like adaptations in zebrafish, revealing conserved exercise responses and novel ETC organization.

bioRxiv · Dec 7, 2018 · PreprintPhysiology