Noboru Mizushima

High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

This study quantifies basal autophagic flux in mice using GFP-LC3-RFP reporter mice, revealing higher flux in brain, liver, and kidney compared to other tissues.

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder

The paper identifies bi-allelic ATG12 variants causing a neurodevelopmental disorder by impairing autophagy, with clinical and functional evidence from patient cells, yeast, and zebrafish models.

ATG gene duplication in vertebrates: evolutionary divergence and its functional implications

This study investigates ATG gene duplication in vertebrates, showing that most ATG genes were duplicated via whole-genome events near the vertebrate root and explores functional divergence patterns among paralogs.

Optogenetic tools for inducing organelle membrane rupture

This paper develops optogenetic tools to induce membrane rupture of specific organelles using engineered BAX proteins with light-sensitive domains.

Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening

The paper develops a method to engineer lipid-binding probes by screening protein-lipid interactions and identifies structural features that enhance binding to phosphatidylinositol phosphates.

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

The paper identifies the triad interaction between ULK1, ATG13, and FIP200 as essential for ULK complex formation and autophagy initiation.

The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate lysosomal stress responses

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

TAX1BP1 recruits ATG9 vesicles through SCAMP3 binding

This study identifies SCAMP3 as the mediator of TAX1BP1-dependent ATG9 vesicle recruitment during selective macroautophagy.