Selena Aranda

Pleiotropic genetic architecture linking schizophrenia and substance use disorders

This study identifies shared genetic architecture between schizophrenia and substance use disorders using GWAS and genomic methods, finding significant genetic correlations and bidirectional causal relationships.

Genotype-Phenotype Correlations and Putative Modifier Genes in SYNGAP1 Encephalopathy

This study investigates genotype-phenotype correlations in SYNGAP1 Encephalopathy, finding that variant location and type, along with modifier genes, influence clinical severity and autistic traits.

Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ~1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets

This study identifies 80 genome-wide significant associations for endometriosis and adenomyosis in 1.4 million women, uncovering novel loci and pathways involved in disease mechanisms.