Di Hu

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

This study benchmarks CUT&Tag against ENCODE ChIP-seq for histone modifications, finding 54% average recall of known peaks and comparable peak caller performance.

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer's disease

This study examines how APOE isoforms affect the transcriptomic and epigenomic features of human microglia in an Alzheimer's disease xenotransplantation model, identifying genotype-dependent differences.

Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm

The paper characterizes the transcriptional dynamics of the mouse Anterior Visceral Enderm (AVE) during migration and identifies Ephrin- and Semaphorin-signalling as critical for its movement.

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

Oscillatory cortical forces promote three dimensional cell intercalations that shape the mandibular arch

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.