Luke P. Newell

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.