Jennifer Lippincott‐Schwartz

Hyperactivation of β-catenin rewires mitochondrial fuel selection in liver cancer cells

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

Non-cell-autonomous removal of protein aggregates via trogocytosis

The paper shows macrophages remove protein aggregates from other cells via trogocytosis, driven by lysosomal stress and tmCSF1 signaling.

Live dynamics of induced cell-cell fusion between mitotic and interphasic cells

This study uses cell-cell fusion to investigate how mitotic and interphase nuclei interact in shared cytoplasm, revealing checkpoint override events and plasticity in cell cycle control.

Lipid Imbalance Generates Golgi Whorls that Sequester Small GTPases

The paper shows lipid imbalance creates Golgi whorls that sequester small GTPases, disrupting trafficking and viability.

Stable Hrd1 tetramers at the heart of the retrotranslocon in living cells

This study uses single-molecule imaging to show that Hrd1 forms stable tetramers in the ER, revealing a conserved hydrophobic motif critical for dislocation.

Pearling Drives Mitochondrial DNA Nucleoid Distribution

The paper shows that mitochondrial DNA nucleoid distribution is controlled by pearling and cristae structure, revealing a mechanism for nucleoid spacing and segregation.

mRNAbow: A versatile gene expression system for multiplexed fluorescent imaging using optimized in vitro transcribed mRNA

The paper develops mRNAbow, a system for generating low-toxicity mRNAs for multiplexed fluorescent imaging in diverse cellular and organismal systems.

Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature

The paper characterizes primary cilia and centriole organization in mouse and human brain microvasculature, revealing interspecies differences and their potential role in sensing microenvironmental signals.

ER-to-Golgi Trafficking is a Nutrient-Sensitive Checkpoint Linking Glucose Starvation to Cell Surface Remodeling

The paper shows glucose starvation impairs ER-to-Golgi trafficking, reducing surface proteins like E-cadherin and promoting metastasis through AMPK and ULK1 signaling.

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

This study identifies RABGAP1 as a sensor that modulates APP trafficking and processing by regulating RAB activity on endosomal subdomains, with implications for Alzheimer's disease.

A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

This paper identifies SLC13A5 as a genetic driver of epileptic encephalopathy that regulates presynaptic glycolysis by clearing axonal citrate during electrical activity.

FilaBuster: A Strategy for Rapid, Specific, and Spatiotemporally Controlled Intermediate Filament Disassembly

FilaBuster enables rapid, specific, and spatiotemporally controlled disassembly of intermediate filaments in living cells using a three-step photochemical strategy.

Transport and Organization of Individual Vimentin Filaments Within Dense Networks Revealed by Single Particle Tracking and 3D FIB-SEM

This study uses single-particle tracking and 3D FIB-SEM to reveal dynamics and organization of individual vimentin filaments within dense networks, showing bidirectional motion and minimal local co-alignment with microtubules.

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

Disruption of TARP-ARC interaction stabilizes synaptic AMPA receptors and rescues social isolation-induced fear memory deficits

This study shows that disrupting the TARP-ARC interaction stabilizes synaptic AMPA receptors and rescues fear memory deficits caused by social isolation in mice.

Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

Oligodendrocyte precursor cells prune axons in the mouse neocortex

The paper identifies oligodendrocyte precursor cells (OPCs) as major contributors to axon pruning in the mouse neocortex through phagocytic activity.

In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning

The paper shows zebrafish stripe patterns arise from in situ differentiation of iridophore crystallotypes, not migration, with distinct transcriptomic and physiological states in stripe and interstripe regions.

Nicotine exposure and neuronal activity regulate Golgi membrane dispersal and distribution

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores

The paper identifies two distinct leucophore populations in zebrafish, showing their different origins and functional roles through single-cell transcriptomics and other analyses.

Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.

Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.