Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G O'Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean-Charles Liévens, Robert P. Bowser, Rita Sattler, Daniela C. Zarnescu
The paper shows that increased glycolysis is neuroprotective in ALS by improving locomotion and lifespan in Drosophila models through glucose transporter and PFK overexpression.
eLife · Jun 10, 2019Peer-reviewedNeuroscience