Erik M. Lehmkuhl

This study shows ADAR2-mediated RNA editing promotes TDP-43 nuclear export and alters its RNA binding, contributing to neurodegenerative disease mechanisms.

The paper identifies TDP-43 proteinopathy's impact on mRNA ribosome association, highlighting Dlp/GPC6 as a novel target in ALS.

The paper shows that increased glycolysis is neuroprotective in ALS by improving locomotion and lifespan in Drosophila models through glucose transporter and PFK overexpression.