TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric B. Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani Bagevalu Siddegowda, Archi Joardar, Hannah E. Ball, Maria E. Macias, Robert P. Bowser, Kendall R. Van Keuren‐Jensen, Daniela C. Zarnescu
The paper identifies TDP-43 proteinopathy's impact on mRNA ribosome association, highlighting Dlp/GPC6 as a novel target in ALS.
Acta Neuropathologica Communications · Mar 24, 2021Peer-reviewedNeuroscience