Annette D. de Kloet

TREM2 Orchestrates Myeloid Cell Programming and Immune Dysregulation in Pulmonary Hypertension

This study identifies TREM2 as a regulator of myeloid cell function and immune dysregulation in pulmonary hypertension, showing its role in disease progression and potential as a therapeutic target.

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

This study identifies vagal afferents expressing the oxytocin receptor that mediate mechanosensation of the heart and gut, leading to hypometabolism and vigilance in mice.

Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.

Central and peripheral GLP-1 systems independently and additively suppress eating

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.

Endogenous oxytocin inhibits hypothalamic stress responsive neurons following acute hypernatremia

This study shows that endogenous oxytocin inhibits hypothalamic CRH neurons during acute hypernatremia, reducing stress responsiveness through Oxtr-dependent mechanisms.

Macrophage-to-sensory neuron crosstalk mediated by Angiotensin II type-2 receptor elicits neuropathic pain

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.