Author

Ryohei Watanabe

University of PennsylvaniaORCID 0000-0002-0775-656XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell-cell communication· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Edward B. LeeiD· 2 shared Angelina Baltazar· 1 shared Benjamin C. CreekmoreiD· 1 shared Bin Zhang· 1 shared Caroline M. O’RourkeiD· 1 shared Courtney L. SmithiD· 1 shared George M. BurslemiD· 1 shared Hong Xu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Edward B. LeeORCID

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2 papers

Recent·Most cited

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Ryohei Watanabe, Edward B. Lee

The paper analyzes cryo-EM data of CTE tau filaments, identifying a new CTE Type I-like structure with a shifted protofilament interface and showing its coexistence with the canonical CTE Type I structure within fibrils.

Biochemical and Biophysical Research Communications · Oct 1, 2026Peer-reviewedMolecular Biology

Repositioning of polyubiquitin alters the pathologic tau filament structure

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha P. Salphati, Lakshmi N. Changolkar, Kevt’her Hoxha, Bin Zhang, Caroline M. O’Rourke, George M. Burslem, Virginia M.‐Y. Lee, Yi‐Wei Chang, Edward B. Lee

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

Nature Structural & Molecular Biology · Aug 31, 2026Peer-reviewedNeuroscience