Lakshmi N. Changolkar

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

This study shows tau pathology spreads along anatomical brain connections and a LRRK2 mutation alters its directionality in mice.