Author

Courtney L. Smith

University of PennsylvaniaORCID 0000-0002-5341-3699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Angelina Baltazar· 1 shared Benjamin C. CreekmoreiD· 1 shared Bin Zhang· 1 shared Caroline M. O’RourkeiD· 1 shared Edward B. LeeiD· 1 shared George M. BurslemiD· 1 shared Hong Xu· 1 shared Kevt’her Hoxha· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Angelina Baltazar

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1 paper

Recent·Most cited

Repositioning of polyubiquitin alters the pathologic tau filament structure

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha P. Salphati, Lakshmi N. Changolkar, Kevt’her Hoxha, Bin Zhang, Caroline M. O’Rourke, George M. Burslem, Virginia M.‐Y. Lee, Yi‐Wei Chang, Edward B. Lee

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

Nature Structural & Molecular Biology · Aug 31, 2026Peer-reviewedNeuroscience