Sarah G. Swygert

The paper investigates how RPA-coated single-stranded DNA regulates condensin loop extrusion in quiescent yeast cells, revealing asymmetric extrusion and a role for transcription-generated topological stress.

The paper shows that chromatin fiber folding in quiescent yeast represses transcription and loop extrusion, with H4 tail modifications affecting fiber structure and function.

This study identifies condensin-mediated chromatin condensation as a mechanism repressing transcription during quiescence in yeast and human cells.