Author

Stephanie Portillo‐Ledesma

New York UniversityORCID 0000-0002-8211-5447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Approach:experimental assay· 2 Approach:simulation· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Tamar Schlick AiD· 3 shared Brianna Kable· 1 shared Cheng-Fu KaoiD· 1 shared Dakota R. Hunt· 1 shared Dejun Lin· 1 shared Evgenya Y. PopovaiD· 1 shared Jill Hoffman· 1 shared Matthew T. SwuliusiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Tamar Schlick AORCID

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3 papers

Recent·Most cited

Compromised 2-start zigzag chromatin folding in immature mouse retina cells driven by irregularly spaced nucleosomes with short DNA linkers.

Brianna Kable, Stephanie Portillo‐Ledesma, Evgenya Y. Popova, Nathan Jentink, Matthew T. Swulius, Zilong Li, Tamar Schlick A, Sergei A. Grigoryev

The paper investigates chromatin structure in immature and mature mouse retina cells, finding that short DNA linkers disrupt the two-start zigzag folding, leading to less compact chromatin in immature cells.

Nucleic Acids Research · May 22, 2025Peer-reviewedMolecular Biology

Regulation of Chromatin Architecture by Transcription Factor Binding

Stephanie Portillo‐Ledesma, Suckwoo Chung, Jill Hoffman, Tamar Schlick A

This study investigates how Myc:Max binding affects chromatin architecture and gene regulation through simulations of chromatin fiber folding and microdomain formation.

eLife · Nov 30, 2023Peer-reviewedGenomics

Chromatin Fiber Folding Represses Transcription and Loop Extrusion in Quiescent Cells

Sarah G. Swygert, Dejun Lin, Stephanie Portillo‐Ledesma, Po-Yen Lin, Dakota R. Hunt, Cheng-Fu Kao, Tamar Schlick A, William Stafford Noble, Toshio Tsukiyama

The paper shows that chromatin fiber folding in quiescent yeast represses transcription and loop extrusion, with H4 tail modifications affecting fiber structure and function.

eLife · Nov 4, 2021Peer-reviewedMolecular Biology