Author

Xiuyuan Lu

Immunology Frontier Research Center, The University of OsakaORCID 0000-0002-0784-2871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

Sho YamasakiiD· 3 shared Daron M. StandleyiD· 2 shared Mara Anaís Llamas-CovarrubiasiD· 2 shared A. SherifiD· 1 shared Arthur MilliusiD· 1 shared Charles R. SchuttiD· 1 shared Deren Birol· 1 shared Floris J. van EerdeniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Sho YamasakiORCID

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3 papers

Recent·Most cited

The presenting HLA determines fidelity of SARS-CoV-2 spike protein epitope prediction

Charles R. Schutt, Deren Birol, Xiuyuan Lu, Sho Yamasaki

The paper compares epitope prediction methods across different HLA types and finds that prediction accuracy varies with HLA, suggesting broader HLA coverage improves epitope identification.

Vaccine · Jun 12, 2025Peer-reviewedImmunology

InterClone: Store, Search and Cluster Adaptive Immune Receptor Repertoires

Jan Wilamowski, Zichang Xu, Hendra Saputra Ismanto, Songling Li, Shunsuke Teraguchi, Mara Anaís Llamas-Covarrubias, Xiuyuan Lu, Sho Yamasaki, Daron M. Standley

InterClone stores, searches, and clusters adaptive immune receptor repertoires, demonstrating its utility in analyzing SARS-CoV-2 antibodies and TCRs from different donor groups.

bioRxiv · Jul 31, 2022 · PreprintBioinformatics

TCR-pMHC complex formation triggers CD3 dynamics

Floris J. van Eerden, A. Sherif, Mara Anaís Llamas-Covarrubias, Arthur Millius, Xiuyuan Lu, Shigenari Ishizuka, Sho Yamasaki, Daron M. Standley

This study identifies an allosteric mechanism where TCR-pMHC binding induces CD3 dynamics through conformational changes, with the TCRβ FG loop acting as a gatekeeper and the connecting peptide as a hinge.

bioRxiv · Jul 27, 2022 · PreprintMolecular Biology