This study identifies persistent immune dysregulation in women with hypertensive disorders of pregnancy years after delivery, linked to increased cardiovascular disease risk.

Frontiers in Immunology · Feb 5, 2026Peer-reviewedImmunology

SPACEc: A Streamlined, Interactive Python Workflow for Multiplexed Image Processing and Analysis

Yuqi Tan, Tim Noah Kempchen, Martin Becker, Maximilian Haist, Dorien Feyaerts, Jiaqi Liu, Marieta Ioana Toma, Yang Xiao, Graham Su, Andrew J. Rech, Michael Hölzel, Rong Fan, John W. Hickey, Garry P. Nolan

SPACEc provides a Python workflow for analyzing multiplexed imaging data with interactive tools for image processing, segmentation, and spatial analysis.

Nature Communications · Nov 27, 2025Peer-reviewedBioinformatics

Single-cell-level digital twins for preterm birth prevention strategies

Jakob F. Einhaus, Peter Neidlinger, Olivier Fondeur, Sato Masaki, Alexandra Anronikov, Kotaro Miyazaki, Jonas N. Amar, Kazuo Ando, Valentin Badea, Dyani Kalea Gaudilliere, Maximilian Sabayev, Dorien Feyaerts, Maïgane Diop, Amy S. Tsai, Amélie I. F. Cambriel, , Brice L Gaudilliere

The paper introduces SIMCO, a single-cell digital twin framework for evaluating PTL prevention drugs, identifying tetrahydrofolate, maprotiline, and aspirin-lansoprazole as top candidates.

bioRxiv · Sep 29, 2025 · PreprintImmunology

An immune signature of postoperative cognitive decline in elderly patients

Franck Verdonk, Amélie I. F. Cambriel, Julien Jacques Hedou, Edward A. Ganio, Grégoire Bellan, Dyani Kalea Gaudilliere, Jakob F. Einhaus, Maximilian Sabayev, Ina Annelies Stelzer, Dorien Feyaerts, Adam T. Bonham, Kazuo Ando, Benjamin Choisy, David R. Drover, Boris Dov Heifets, , Brice L Gaudilliere

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

bioRxiv · Mar 2, 2024 · PreprintNeuroscience