Belén Borrego

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever Virus

This study uses codon deoptimization to create attenuated Rift Valley Fever Virus (RVFV) vaccine candidates, showing varying degrees of attenuation with the dual-segment deoptimized virus as a promising live-attenuated vaccine.

The route of infection shapes Rift Valley fever virus pathogenesis, humoral immune response, and horizontal transmission in sheep.

This study compares subcutaneous and intranasal infection routes of RVFV in sheep, showing differences in disease progression, immune response, and horizontal transmission.

The hyper-attenuated RVFV 40Fp8 strain can be safely administered to pregnant ewes to protect them from a virulent challenge

This study evaluates the safety and protective efficacy of the RVFV-40Fp8 strain in pregnant ewes, showing no fetal damage and protection against a virulent challenge.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.