Sandra Moreno

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever Virus

This study uses codon deoptimization to create attenuated Rift Valley Fever Virus (RVFV) vaccine candidates, showing varying degrees of attenuation with the dual-segment deoptimized virus as a promising live-attenuated vaccine.

Generation and characterization of an ovine cell line derived from peripheral blood and its potential use to study livestock and zoonotic viral infections

This paper establishes and characterizes an ovine mesenchymal stromal cell line from peripheral blood, confirming its mesenchymal origin and susceptibility to various viruses.

The hyper-attenuated RVFV 40Fp8 strain can be safely administered to pregnant ewes to protect them from a virulent challenge

This study evaluates the safety and protective efficacy of the RVFV-40Fp8 strain in pregnant ewes, showing no fetal damage and protection against a virulent challenge.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.

The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculation

The paper evaluates the safety of the RVF vaccine candidate 40Fp8 in immunosuppressed mice, showing it is highly attenuated compared to other vaccine viruses.