Aitor Nogales

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever Virus

This study uses codon deoptimization to create attenuated Rift Valley Fever Virus (RVFV) vaccine candidates, showing varying degrees of attenuation with the dual-segment deoptimized virus as a promising live-attenuated vaccine.

Enhanced Pathogenicity and Contact Transmissibility of Human-origin Avian Influenza H5N1 Clade 2.3.4.4b Genotype B3.13 Compared to D1.1 in Ferrets

This study compares the pathogenicity and transmissibility of two H5N1 genotypes in ferrets, finding B3.13 is more pathogenic and transmissible than D1.1, while D1.1 acquires adaptive mutations rapidly.

A One-Shot Multivalent Live-Attenuated Candidate Influenza Vaccine against Divergent Zoonotic H5N1 Clades

This paper develops a multivalent live-attenuated influenza vaccine that provides broad protection against multiple H5N1 clades by incorporating HA and NA from representative clades, showing robust immune responses and protection in mice.

Neuraminidase-Based Cross-Protective Immunity against H5N1 Influenza Viruses in Humans

This study shows that NA-specific antibodies are present in human sera and can be boosted by seasonal vaccination against H5N1 influenza viruses.

Generation and characterization of an ovine cell line derived from peripheral blood and its potential use to study livestock and zoonotic viral infections

This paper establishes and characterizes an ovine mesenchymal stromal cell line from peripheral blood, confirming its mesenchymal origin and susceptibility to various viruses.

Bioluminescent reporter influenza A viruses to track viral infections

This paper develops recombinant influenza A viruses expressing nanoluciferase for in vitro and in vivo tracking of viral infections, showing they replicate efficiently and can be imaged using IVIS.

A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions

This paper develops a bioluminescent H5N1 influenza virus to track infection and test antiviral drugs in vitro and in vivo.

Targeting ROCK Signaling Mitigates Influenza Virus-Induced Fibrogenesis in Human Airway Organoids

This study shows that inhibiting the ROCK signaling pathway reduces influenza virus-induced fibrosis in human airway organoids.

A Live Attenuated Vaccine Candidate against Emerging Highly Pathogenic Cattle-Origin 2.3.4.4b H5N1 Viruses

This paper develops a live attenuated vaccine candidate, LPhTXdNS1, against H5N1 influenza viruses and shows it is safe, immunogenic, and protective in mice.

Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us?

This study assesses serological protection against H5N1 and H7N9 avian influenza viruses and evaluates the effectiveness of seasonal flu vaccines in inducing protective immunity.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.