Alejandro Brun

This study uses codon deoptimization to create attenuated Rift Valley Fever Virus (RVFV) vaccine candidates, showing varying degrees of attenuation with the dual-segment deoptimized virus as a promising live-attenuated vaccine.

This study compares subcutaneous and intranasal infection routes of RVFV in sheep, showing differences in disease progression, immune response, and horizontal transmission.

This paper establishes and characterizes an ovine mesenchymal stromal cell line from peripheral blood, confirming its mesenchymal origin and susceptibility to various viruses.

This study evaluates the safety and protective efficacy of the RVFV-40Fp8 strain in pregnant ewes, showing no fetal damage and protection against a virulent challenge.

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.

The paper evaluates the safety of the RVF vaccine candidate 40Fp8 in immunosuppressed mice, showing it is highly attenuated compared to other vaccine viruses.