The paper develops a mathematical model to quantify how Golgi cisterna morphology affects glycosylation efficiency, identifying optimal and maximal thicknesses for successful polymer production.

PLoS Computational Biology · Mar 6, 2026Peer-reviewedBiophysics

Apical Size Reduction by Macropinocytosis Alleviates Tissue Crowding

Enzo Bresteau, Eve E Suva, Christopher K. Revell, Osama A. Hassan, Aline Grata, Jennifer Sheridan, Jennifer Mitchell, Constadina Arvanitis, Farida V. Korobova, Sarah Woolner, Oliver E. Jensen, Brian Mitchell

The paper shows that macropinocytosis reduces cell size to alleviate tissue crowding, working alongside cell extrusion.

Nature Communications · Jun 23, 2025Peer-reviewedCell Biology

Notch controls the cell cycle to define leader versus follower identities during collective cell migration.

Zain Alhashem, Dylan Feldner-Busztin, Christopher K. Revell, Macarena Alvarez-Garcillan Portillo, Karen Camargo Sosa, Joanna Richardson, Manuel Rocha, Anton Gauert, Tatianna Corbeaux, Martina Milanetto, Francesco Argenton, Natascia Tiso, Robert Neil Kelsh, Victoria Prince, Katie Bentley, Claudia Linker

This study shows Notch signaling controls cell cycle progression to define leader and follower identities during zebrafish Trunk Neural Crest migration.

eLife · Apr 19, 2022Peer-reviewedDevelopmental Biology

Cell surface fluctuations regulate early embryonic lineage sorting

Ayaka Yanagida, Elena Corujo-Simón, Christopher K. Revell, Preeti Sahu, Giuliano Giuseppe Stirparo, Irene M. Aspalter, Alexander K. Winkel, Ruby Peters, Henry De Belly, Davide A. D. Cassani, Sarra Achouri, Raphaël Blumenfeld, Kristian Franze, Édouard Hannezo, Ewa K. Paluch, , Kevin J. Chalut

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

Cell · Feb 22, 2022Peer-reviewedDevelopmental Biology