ASO-mediated mRNA silencing enables functional analysis and selective depletion of the human microbiota Prevotellaceae
Valentina Cosi, Vincent Lau, Petia Kovatcheva‐Datchary, Youssef El Mouali, Toby Wilkinson, Victoria Gebler, Linda Popella, Franziska Faber, Till Strowig, Jörg Vogel
This study uses ASOs to selectively inhibit mRNA translation in Prevotellaceae species, enabling functional analysis and targeted depletion in synthetic communities.
bioRxiv · Apr 18, 2026 · PreprintMicrobiology